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1

Arginase: A Multifaceted Enzyme Important in Health and Disease

Caldwell, R. William, Rodriguez, Paulo C., Toque, Haroldo A., Narayanan, S. Priya, Caldwell, Ruth B.

Journal:

Physiological Reviews

Année:

2018

Langue:

english

Fichier:

PDF, 723 KB

english, 2018

2

Hyperglycemia-impaired aortic vasorelaxation mediated through arginase elevation: Role of stress kinase pathways

Chandra, Surabhi, Fulton, David J.R., Caldwell, Ruth B., Caldwell, R. William, Toque, Haroldo A.

Journal:

European Journal of Pharmacology

Année:

2019

Langue:

english

Fichier:

PDF, 2.16 MB

english, 2019

3

Effect of new sildenafil analogues in the rabbit isolated aorta

Haroldo A Flores Toque, Fernanda BM Priviero, Cleber E Teixeira, Edson Antunes, Gilberto de Nucci

Journal:

BMC Pharmacology

Année:

2007

Langue:

english

Fichier:

PDF, 448 KB

english, 2007

4

Mechanisms of relaxant activity of BAY 41-2272 in rat tracheal smooth musclein vitro

Haroldo AF Toque, Rafael P Morganti, Gilberto De Nucci, Edson Antunes

Journal:

BMC Pharmacology

Année:

2009

Langue:

english

Fichier:

PDF, 71 KB

english, 2009

5

VASORELAXING EFFECTS OF PROPRANOLOL IN RAT AORTA AND MESENTERIC ARTERY: A ROLE FOR NITRIC OXIDE AND CALCIUM ENTRY BLOCKADE

Fernanda BM Priviero, Cleber E Teixeira, Haroldo AF Toque, Mário A Claudino, R Clinton Webb, Gilberto De Nucci, Angelina Zanesco, Edson Antunes

Journal:

Clinical and Experimental Pharmacology and Physiology

Année:

2006

Langue:

english

Fichier:

PDF, 251 KB

english, 2006

6

EFFECT OF THE PHOSPHODIESTERASE 5 INHIBITORS SILDENAFIL, TADALAFIL AND VARDENAFIL ON RAT ANOCOCCYGEUS MUSCLE: FUNCTIONAL AND BIOCHEMICAL ASPECTS

Haroldo A Toque, Fernanda BM Priviero, Saiprasad M Zemse, Edson Antunes, Cleber E Teixeira, R Clinton Webb

Journal:

Clinical and Experimental Pharmacology and Physiology

Année:

2009

Langue:

english

Fichier:

PDF, 453 KB

english, 2009

7

High-fat diet associated with obesity induces impairment of mouse corpus cavernosum responses

Haroldo A. Toque, Fábio H. da Silva, Marina C. Calixto, Letícia Lintomen, André A. Schenka, Mario J. Saad, Angelina Zanesco, Edson Antunes

Journal:

BJU International

Année:

2011

Langue:

english

Fichier:

PDF, 744 KB

english, 2011

8

Tetrahydropalmatine protects against methamphetamine-induced spatial learning and memory impairment in mice

Yan-Jiong Chen, Yan-Ling Liu, Qing Zhong, Yan-Fang Yu, Hong-Liang Su, Haroldo A. Toque, Yong-Hui Dang, Feng Chen, Ming Xu, Teng Chen

Journal:

Neuroscience Bulletin

Année:

2012

Langue:

english

Fichier:

PDF, 883 KB

english, 2012

9

Pharmacological characterization of a novel phosphodiesterase type 5 (PDE5) inhibitor lodenafil carbonate on human and rabbit corpus cavernosum

Haroldo A. Toque, Cleber E. Teixeira, Raquel Lorenzetti, Cristina E. Okuyama, Edson Antunes, Gilberto De Nucci

Journal:

European Journal of Pharmacology

Année:

2008

Langue:

english

Fichier:

PDF, 713 KB

english, 2008

10

Mechanisms of relaxant activity of the nitric oxide-independent soluble guanylyl cyclase stimulator BAY 41-2272 in rat tracheal smooth muscle

Haroldo A. Toque, Fabíola Z.T. Mónica, Rafael P. Morganti, Gilberto De Nucci, Edson Antunes

Journal:

European Journal of Pharmacology

Année:

2010

Langue:

english

Fichier:

PDF, 530 KB

english, 2010

11

p38 Mitogen-Activated Protein Kinase (MAPK) Increases Arginase Activity and Contributes to Endothelial Dysfunction in Corpora Cavernosa from Angiotensin-II-Treated Mice

Haroldo A. Toque, Maritza J. Romero, Rita C. Tostes, Alia Shatanawi, Surabhi Chandra, Zidonia N. Carneiro, Edward W. Inscho, Robert Clinton Webb, Ruth B. Caldwell, Robert William Caldwell

Journal:

The Journal of Sexual Medicine

Année:

2010

Langue:

english

Fichier:

PDF, 429 KB

english, 2010

12

Arginase II Deletion Increases Corpora Cavernosa Relaxation in Diabetic Mice

Haroldo A. Toque, Rita C. Tostes, Lin Yao, Zhimin Xu, R. Clinton Webb, Ruth B. Caldwell, R. William Caldwell

Journal:

The Journal of Sexual Medicine

Année:

2011

Langue:

english

Fichier:

PDF, 335 KB

english, 2011

13

Extracellular Signal-Regulated Kinase (ERK) Inhibition Decreases Arginase Activity and Improves Corpora Cavernosal Relaxation in Streptozotocin (STZ)-Induced Diabetic Mice

Kenia P. Nunes, Haroldo A. Toque, Ruth B. Caldwell, R. William Caldwell, R. Clinton Webb

Journal:

The Journal of Sexual Medicine

Année:

2011

Langue:

english

Fichier:

PDF, 408 KB

english, 2011

14

Increased Cyclic Guanosine Monophosphate Synthesis and Calcium Entry Blockade Account for the Relaxant Activity of the Nitric Oxide–Independent Soluble Guanylyl Cyclase Stimulator BAY 41-2272 in the Rabbit Penile Urethra

Haroldo A. Flores Toque, Edson Antunes, Cleber E. Teixeira, Gilberto De Nucci

Journal:

Année:

2008

Langue:

english

Fichier:

PDF, 264 KB

english, 2008

15

Comparative Relaxing Effects of Sildenafil, Vardenafil, and Tadalafil in Human Corpus Cavernosum: Contribution of Endogenous Nitric Oxide Release

Haroldo A. Toque, Fernanda B.M. Priviero, Cleber E. Teixeira, Mário A. Claudino, Juliana S. Baracat, Adriano Fregonesi, Gilberto De Nucci, Edson Antunes

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 823 KB

english, 2009

16

Erectile Function Is Improved in Aged Rats by PnTx2-6, a Toxin from Phoneutria nigriventer Spider Venom

Kenia P. Nunes, Haroldo A. Toque, Marcia H. Borges, Michael Richardson, R. Clinton Webb, Maria Elena de Lima

Journal:

The Journal of Sexual Medicine

Année:

2012

Langue:

english

Fichier:

PDF, 507 KB

english, 2012

17

Superoxide Anion Production by NADPH Oxidase Plays a Major Role in Erectile Dysfunction in Middle-Aged Rats: Prevention by Antioxidant Therapy

Silva, Fábio H., Mónica, Fabíola Z., Báu, Fernando R., Brugnerotto, Ana F., Priviero, Fernanda B.M., Toque, Haroldo A., Antunes, Edson

Journal:

The Journal of Sexual Medicine

Année:

2013

Langue:

english

Fichier:

PDF, 706 KB

english, 2013

18

Activated Rho Kinase Mediates Diabetes-Induced Elevation of Vascular Arginase Activation and Contributes to Impaired Corpora Cavernosa Relaxation: Possible Involvement of p38 MAPK Activation

Toque, Haroldo A., Nunes, Kenia P., Yao, Lin, Liao, James K., Webb, R. Clinton, Caldwell, Ruth B., Caldwell, R. William

Journal:

The Journal of Sexual Medicine

Année:

2013

Langue:

english

Fichier:

PDF, 821 KB

english, 2013

19

Synthesis and Pharmacological Evaluations of Sildenafil Analogues for Treatment of Erectile Dysfunction

Flores Toque, Haroldo A., Priviero, Fernanda B. M., Teixeira, Cleber E., Perissutti, Elisa, Fiorino, Ferdinando, Severino, Beatrice, Frecentese, Francesco, Lorenzetti, Raquel, Baracat, Juliana S., San

Journal:

Journal of Medicinal Chemistry

Année:

2008

Langue:

english

Fichier:

PDF, 181 KB

english, 2008

20

The role of RhoA/Rho kinase pathway in endothelial dysfunction

Yang, Guang, Caldwell, Ruth B., Yao, Lin, Romero, Maritza J., Toque, Haroldo A., Caldwell, R. William

Journal:

Journal of Cardiovascular Disease Research

Année:

2010

Langue:

english

Fichier:

PDF, 182 KB

english, 2010

21

Arginase in retinopathy

Narayanan, S. Priya, Rojas, Modesto, Suwanpradid, Jutamas, Toque, Haroldo A., Caldwell, R. William, Caldwell, Ruth B.

Journal:

Progress in Retinal and Eye Research

Année:

2013

Langue:

english

Fichier:

PDF, 3.97 MB

english, 2013

22

Protein kinase RNA-like endoplasmic reticulum kinase (PERK)/calcineurin signaling is a novel pathway regulating intracellular calcium accumulation which might be involved in ventricular arrhythmias in diabetic cardiomyopathy

Liu, Zhongwei, Cai, Hui, Zhu, Haitao, Toque, Haroldo, Zhao, Na, Qiu, Chuan, Guan, Gongchang, Dang, Yonghui, Wang, Junkui

Journal:

Cellular Signalling

Année:

2014

Langue:

english

Fichier:

PDF, 1.89 MB

english, 2014

23

New approaches to the design and discovery of therapies to prevent erectile dysfunction

Toque, Haroldo A, Caldwell, Robert William

Journal:

Expert Opinion on Drug Discovery

Année:

2014

Langue:

english

Fichier:

PDF, 784 KB

english, 2014

24

Arginase inhibition enhances angiogenesis in endothelial cells exposed to hypoxia

Wang, Lin, Bhatta, Anil, Toque, Haroldo A., Rojas, Modesto, Yao, Lin, Xu, Zhimin, Patel, Chintan, Caldwell, Ruth B., Caldwell, R. William

Journal:

Microvascular Research

Année:

2015

Langue:

english

Fichier:

PDF, 1.60 MB

english, 2015

25

Arginase: an old enzyme with new tricks

Caldwell, Ruth B., Toque, Haroldo A., Narayanan, S. Priya, Caldwell, R. William

Journal:

Trends in Pharmacological Sciences

Année:

2015

Langue:

english

Fichier:

PDF, 951 KB

english, 2015

26

Arginase 1 Mediates Increased Blood Pressure and Contributes to Vascular Endothelial Dysfunction in Deoxycorticosterone Acetate-Salt Hypertension

Toque, Haroldo A., Nunes, Kenia P., Rojas, Modesto, Bhatta, Anil, Yao, Lin, Xu, Zhimin, Romero, Maritza J., Webb, R. Clinton, Caldwell, Ruth B., Caldwell, R. William

Journal:

Frontiers in Immunology

Année:

2013

Langue:

english

Fichier:

PDF, 1.43 MB

english, 2013

27

Deregulation of arginase induces bone complications in high-fat/high-sucrose diet diabetic mouse model

Bhatta, Anil, Sangani, Rajnikumar, Kolhe, Ravindra, Toque, Haroldo A., Cain, Michael, Wong, Abby, Howie, Nicole, Shinde, Rahul, Elsalanty, Mohammed, Yao, Lin, Chutkan, Norman, Hunter, Monty, Caldwell,

Journal:

Molecular and Cellular Endocrinology

Année:

2016

Langue:

english

Fichier:

PDF, 1.99 MB

english, 2016

28

Mitochondrial targeting by dichloroacetate improves outcome following hemorrhagic shock

Subramani, Kumar, Lu, Sumin, Warren, Marie, Chu, Xiaogang, Toque, Haroldo A., Caldwell, R. William, Diamond, Michael P., Raju, Raghavan

Journal:

Scientific Reports

Année:

2017

Langue:

english

Fichier:

PDF, 4.25 MB

english, 2017

29

Obesity-induced vascular inflammation involves elevated arginase activity

Yao, Lin, Bhatta, Anil, Xu, Zhimin, Chen, Jijun, Toque, Haroldo A, Chen, Yongjun, Xu, Yiming, Bagi, Zsolt, Lucas, Rudolf, Huo, Yuqing, Caldwell, Ruth B., Caldwell, Robert W.

Journal:

American Journal of Physiology - Regulatory, Integrative and Comparative Physiology

Année:

2017

Langue:

english

Fichier:

PDF, 2.79 MB

english, 2017

30

Toll-like receptor 4 (TLR4) impairs nitric oxide contributing to Angiotensin II-induced cavernosal dysfunction

Nunes, Kenia P., Bomfim, Gisele F., Toque, Haroldo A., Szasz, Theodora, Clinton Webb, R.

Journal:

Année:

2017

Langue:

english

Fichier:

PDF, 1.36 MB

english, 2017

31

Obesity-induced vascular dysfunction and arterial stiffening requires endothelial cell arginase 1

Bhatta, Anil, Yao, Lin, Xu, Zhimin, Toque, Haroldo A., Chen, Jijun, Atawia, Reem T., Fouda, Abdelrahman Y., Bagi, Zsolt, Lucas, Rudolf, Caldwell, Ruth B., Caldwell, Robert W.

Journal:

Cardiovascular Research

Année:

2017

Langue:

english

Fichier:

PDF, 1.08 MB

english, 2017

32

Regulation of endothelial intracellular adenosine via adenosine kinase epigenetically modulates vascular inflammation

Xu, Yiming, Wang, Yong, Yan, Siyuan, Yang, Qiuhua, Zhou, Yaqi, Zeng, Xianqiu, Liu, Zhiping, An, Xiaofei, Toque, Haroldo A., Dong, Zheng, Jiang, Xuejun, Fulton, David J., Weintraub, Neal L., Li, Qinkai

Journal:

Nature Communications

Année:

2017

Langue:

english

Fichier:

PDF, 6.09 MB

english, 2017

33

Akita Spontaneously Type 1 Diabetic Mice Exhibit Elevated Vascular Arginase and Impaired Vascular Endothelial and Nitrergic Function

Toque, Haroldo A., Nunes, Kenia P., Yao, Lin, Xu, Zhimin, Kondrikov, Dmitry, Su, Yunchao, Webb, R. Clinton, Caldwell, Ruth B., Caldwell, R. William, Emanueli, Costanza

Journal:

Année:

2013

Langue:

english

Fichier:

PDF, 1.91 MB

english, 2013

34

Requirement of NOX2 Expression in Both Retina and Bone Marrow for Diabetes-Induced Retinal Vascular Injury

Rojas, Modesto, Zhang, Wenbo, Xu, Zhimin, Lemtalsi, Tahira, Chandler, Phillip, Toque, Haroldo A., Caldwell, Robert W., Caldwell, Ruth B., Ushio-Fukai, Masuko

Journal:

Année:

2013

Langue:

english

Fichier:

PDF, 1.94 MB

english, 2013

35

Impaired Corpus Cavernosum Relaxation Is Accompanied by Increased Oxidative Stress and Up-Regulation of the Rho-Kinase Pathway in Diabetic (Db/Db) Mice

Priviero, Fernanda B. M., Toque, Haroldo A. F., Nunes, Kenia Pedrosa, Priolli, Denise G., Teixeira, Cleber E., Webb, R. Clinton, Ushio-Fukai, Masuko

Journal:

Année:

2016

Langue:

english

Fichier:

PDF, 2.17 MB

english, 2016

36

NOX2-Induced Activation of Arginase and Diabetes-Induced Retinal Endothelial Cell Senescence

Rojas, Modesto, Lemtalsi, Tahira, Toque, Haroldo, Xu, Zhimin, Fulton, David, Caldwell, Robert, Caldwell, Ruth

Journal:

Année:

2017

Langue:

english

Fichier:

PDF, 4.13 MB

english, 2017

37

Arginase 1 promotes retinal neurovascular protection from ischemia through suppression of macrophage inflammatory responses

Fouda, Abdelrahman Y., Xu, Zhimin, Shosha, Esraa, Lemtalsi, Tahira, Chen, Jijun, Toque, Haroldo A., Tritz, Rebekah, Cui, Xuezhi, Stansfield, Brian K., Huo, Yuqing, Rodriguez, Paulo C., Smith, Sylvia B

Journal:

Cell Death and Disease

Année:

2018

Langue:

english

Fichier:

PDF, 2.87 MB

english, 2018

38

The TNF-derived TIP peptide activates the epithelial sodium channel and ameliorates experimental nephrotoxic serum nephritis

Madaio, Michael P., Czikora, Istvan, Kvirkvelia, Nino, McMenamin, Malgorzata, Yue, Qiang, Liu, Ting, Toque, Haroldo A., Sridhar, Supriya, Covington, Katherine, Alaisami, Rabei, O’Connor, Paul M., Cald

Journal:

Kidney International

Année:

2019

Fichier:

PDF, 3.47 MB

2019

39

Age-Dependent Oxidative Stress Elevates Arginase 1 and Uncoupled Nitric Oxide Synthesis in Skeletal Muscle of Aged Mice

Pandya, Chirayu D., Lee, Byung, Toque, Haroldo A., Mendhe, Bharati, Bragg, Robert T., Pandya, Bhaumik, Atawia, Reem T., Isales, Carlos, Hamrick, Mark, Caldwell, R. William, Fulzele, Sadanand

Journal:

Oxidative Medicine & Cellular Longevity

Année:

2019

Langue:

english

Fichier:

PDF, 3.79 MB

english, 2019

40

Age-Dependent Oxidative Stress Elevates Arginase 1 and Uncoupled Nitric Oxide Synthesis in Skeletal Muscle of Aged Mice

Pandya, Chirayu D., Lee, Byung, Toque, Haroldo A., Mendhe, Bharati, Bragg, Robert T., Pandya, Bhaumik, Atawia, Reem T., Isales, Carlos, Hamrick, Mark, Caldwell, R. William, Fulzele, Sadanand

Journal:

Oxidative Medicine & Cellular Longevity

Année:

2019

Fichier:

PDF, 3.79 MB

2019

41

Impact of Bacterial Toxins in the Lungs

Lucas, Rudolf, Hadizamani, Yalda, Gonzales, Joyce, Gorshkov, Boris, Bodmer, Thomas, Berthiaume, Yves, Moehrlen, Ueli, Lode, Hartmut, Huwer, Hanno, Hudel, Martina, Mraheil, Mobarak Abu, Toque, Haroldo

Journal:

Année:

2020

Fichier:

PDF, 3.17 MB

2020

42

Dual role of hydrogen peroxide as an oxidant in pneumococcal pneumonia

Mraheil, Mobarak Abu, Toque, Haroldo A., La Pietra, Luigi, Hamacher, Juerg, Phanthok, Tenzing, Verin, Alexander D, Gonzales, Joyce, Su, Yunchao, Fulton, David, Eaton, Douglas C, Chakraborty, Trinad, L

Journal:

Antioxidants & Redox Signaling

Année:

2020

Fichier:

PDF, 1.30 MB

2020